JPH0148895B2 - - Google Patents

Info

Publication number
JPH0148895B2
JPH0148895B2 JP56125412A JP12541281A JPH0148895B2 JP H0148895 B2 JPH0148895 B2 JP H0148895B2 JP 56125412 A JP56125412 A JP 56125412A JP 12541281 A JP12541281 A JP 12541281A JP H0148895 B2 JPH0148895 B2 JP H0148895B2
Authority
JP
Japan
Prior art keywords
methyl
group
indol
ethyl
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP56125412A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5759864A (en
Inventor
Harorudo Kootesu Ian
Miruzu Kiisu
Furederitsuku Uebu Korin
Denisu Dauru Maikeru
Edomondo Beizu Debitsudo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of JPS5759864A publication Critical patent/JPS5759864A/ja
Publication of JPH0148895B2 publication Critical patent/JPH0148895B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP56125412A 1980-08-12 1981-08-12 Organic compound, manufacture and composition containing same Granted JPS5759864A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8026288 1980-08-12

Publications (2)

Publication Number Publication Date
JPS5759864A JPS5759864A (en) 1982-04-10
JPH0148895B2 true JPH0148895B2 (en]) 1989-10-20

Family

ID=10515412

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56125412A Granted JPS5759864A (en) 1980-08-12 1981-08-12 Organic compound, manufacture and composition containing same

Country Status (28)

Country Link
US (2) US4672067A (en])
JP (1) JPS5759864A (en])
AR (1) AR231533A1 (en])
AT (1) AT381304B (en])
AU (1) AU548270B2 (en])
BE (1) BE889930A (en])
CA (2) CA1169077A (en])
CH (1) CH651550A5 (en])
DE (1) DE3131748A1 (en])
DK (1) DK157680C (en])
ES (2) ES504695A0 (en])
FI (1) FI812475L (en])
FR (1) FR2488605A1 (en])
GB (1) GB2081717B (en])
GR (1) GR74536B (en])
IE (1) IE51492B1 (en])
IL (1) IL63541A (en])
IT (1) IT1171451B (en])
LU (1) LU83546A1 (en])
MY (1) MY8600577A (en])
NL (1) NL8103768A (en])
NO (1) NO812722L (en])
NZ (1) NZ197997A (en])
PH (1) PH17428A (en])
PT (1) PT73503B (en])
SE (1) SE454881B (en])
ZA (1) ZA815539B (en])
ZW (1) ZW19381A1 (en])

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79215B (en]) * 1982-06-07 1984-10-22 Glaxo Group Ltd
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
HU196752B (en) * 1983-12-06 1989-01-30 Glaxo Group Ltd Process for production of medical compositions containing indole-derivatives and these compounds
GB8332434D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Production of chemical compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
DE3678805D1 (de) * 1985-11-08 1991-05-23 Glaxo Group Ltd Indolderivate.
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
DE3613623A1 (de) * 1986-04-23 1987-10-29 Bayer Ag N-dihydroindolylethyl-sulfonamide
GB8615599D0 (en) * 1986-06-26 1986-07-30 Glaxo Group Ltd Chemical compounds
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
CA2042295A1 (fr) * 1990-05-15 1991-11-16 Jacques Chauveau Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
HU219974B (hu) * 1990-06-07 2001-10-28 Astrazeneca Ab, Heterociklusos csoporttal helyettesített indolszármazék, előállítása és a vegyületet hatóanyagként tartalmazó gyógyszerkészítmények
GB9022250D0 (en) * 1990-10-12 1990-11-28 Glaxo Group Ltd Medicaments
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
ES2104733T3 (es) * 1990-10-15 1997-10-16 Pfizer Derivados de indol.
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
GB9103770D0 (en) * 1991-02-22 1991-04-10 Glaxo Group Ltd Chemical compounds
ES2033578B1 (es) * 1991-06-06 1995-01-16 Quimica Sint S A Con El 50 Procedimiento para la obtencion de 3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida.
ES2033577B1 (es) * 1991-06-06 1995-01-16 Quimica Sint S A Con El 50 Procedimiento para la obtencion de la 2-carboxi-3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida y sus esteres alquilicos inferiores.
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
ES2122289T3 (es) * 1993-08-31 1998-12-16 Pfizer Derivados de 5-arilindol.
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
GB9417310D0 (en) * 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
AU7261196A (en) * 1995-10-10 1997-04-30 Eli Lilly And Company N-{2-substituted-3-(2-aminoethyl)-1h-indol-5-yl}-amides: new 5-ht1f agonists
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
US20030096379A1 (en) * 2001-03-28 2003-05-22 Kilgore James L. Method for producing tryptamine derivatives
WO2002083771A1 (fr) * 2001-04-13 2002-10-24 Organo Corporation Echangeur d'ions
DK1883451T3 (da) * 2005-04-13 2011-03-14 Neuraxon Inc Substituerede indolforbindelser med NOS-hæmmende virkning
HK1254670A1 (zh) 2015-07-02 2019-07-26 Civitas Therapeutics, Inc. 曲普坦粉末用於肺部给药

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2870162A (en) * 1954-04-28 1959-01-20 Upjohn Co Production of certain tryptamines and compounds produced in the process
BE632051A (fr) * 1963-05-08 1963-11-18 Sandoz Sa Nouveaux dérivés de l'indole et leur préparation.
CH442303A (de) * 1964-06-26 1967-08-31 Sandoz Ag Verfahren zur Herstellung von neuen Indol-Derivaten
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
FR2334358A1 (fr) * 1975-12-12 1977-07-08 Sogeras Nouveaux medicaments derives de l'indole
US4180509A (en) * 1977-07-01 1979-12-25 Merrell Toraude Et Compagnie α-Ethynyl tryptophanes
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
CA1169429A (en) 1984-06-19
ES8404327A1 (es) 1984-04-16
BE889930A (fr) 1982-02-11
IT8149086A0 (it) 1981-08-11
DK157680C (da) 1990-07-09
AU7399681A (en) 1982-02-18
ES8300700A1 (es) 1982-11-01
DK357181A (da) 1982-02-13
MY8600577A (en) 1986-12-31
FR2488605B1 (en]) 1984-11-16
DE3131748A1 (de) 1982-04-01
NL8103768A (nl) 1982-03-01
AR231533A1 (es) 1984-12-28
IE51492B1 (en) 1987-01-07
US4636521A (en) 1987-01-13
NO812722L (no) 1982-02-15
PH17428A (en) 1984-08-20
LU83546A1 (fr) 1983-06-08
ZW19381A1 (en) 1983-03-09
AT381304B (de) 1986-09-25
CH651550A5 (fr) 1985-09-30
AU548270B2 (en) 1985-12-05
ATA352881A (de) 1986-02-15
ZA815539B (en) 1983-03-30
PT73503B (en) 1983-09-14
JPS5759864A (en) 1982-04-10
ES513935A0 (es) 1984-04-16
NZ197997A (en) 1985-08-16
CA1169077A (en) 1984-06-12
DK157680B (da) 1990-02-05
US4672067A (en) 1987-06-09
GB2081717A (en) 1982-02-24
SE8104782L (sv) 1982-02-13
FR2488605A1 (fr) 1982-02-19
SE454881B (sv) 1988-06-06
IT1171451B (it) 1987-06-10
FI812475A7 (fi) 1982-02-13
IL63541A (en) 1985-08-30
GB2081717B (en) 1983-09-28
DE3131748C2 (en]) 1992-04-23
IE811831L (en) 1982-02-12
FI812475L (fi) 1982-02-13
PT73503A (en) 1981-09-01
ES504695A0 (es) 1982-11-01
GR74536B (en]) 1984-06-29

Similar Documents

Publication Publication Date Title
JPH0148895B2 (en])
US4816470A (en) Heterocyclic compounds
JPH062733B2 (ja) インド−ル誘導体、その製法及びそれを含む医薬組成物
KR930003759B1 (ko) 인돌 유도체의 제조방법
US5571833A (en) Tryptamine analogues, their synthesis and their use as 5-HT1 -like or 5-HT2 receptor agonists
JP2802169B2 (ja) 片頭痛に用いる５−ｈｔ▲下１▼様アゴニストとしてのインドール誘導体
US4650810A (en) Indole-5-acetamides for treatment of migraine
JPH0148896B2 (en])
GB2162522A (en) An indole derivative
KR19990072124A (ko) 고나도트로핀 방출 호르몬의 길항제
HUT74090A (en) Indole derivatives, process for producing them and pharmaceutical compositions containing them
JPH04235164A (ja) ３−アリールカルボニル−１−アミノアルキル−１ｈ−インドール含有抗緑内障組成物
NZ197998A (en) 5-amino(methyl)-1h-indol-3-ylalkaneamines
CH667454A5 (fr) Derives d'indoles.
GB2186874A (en) Pharmaceutically active 5-acylaminoalkyl-3-aminoalkyl-1H-indoles
US4980368A (en) Tryptamine compounds, and methods of cerebrovascular treatment therewith
JP2902484B2 (ja) ５ｈｔ１−様作動薬としてのインドール誘導体
DK165976B (da) 5-aminosulfonyl-methyl-indolderivater og farmaceutiske praeparater med indhold deraf